BLUHM CARDIOVASCULAR INSTITUTE

Transcatheter Heart Valve Therapies for the Aortic Valve

As one of the highest volume and most experienced transcatheter aortic heart valve replacement (TAVR) programs in the nation, Northwestern Medicine continues to expand its Transcatheter Heart Valve Program by offering a wide array of commercially available therapies and clinical trial options to treat the aortic valve, including TAVR for low-risk patients.

LEARN MORE

312.NM.HEART (312.664.3278) | heart.nm.org | Inquiries: BCVI_info@nm.org

All Rights Reserved. ©2019 by Northwestern Medicine® and Northwestern Memorial HealthCare. 

Northwestern Medicine® is a trademark of Northwestern Memorial HealthCare, used by Northwestern University.

Northwestern Medicine ® | 251 E Huron Street | Chicago, IL 60611 | nm.org

Meet the Team

Bluhm Cardiovascular Institute at Northwestern Memorial Hospital
 675 N. Saint Clair Street
 Galter Pavilion, Suite 19-100
 Chicago, IL 60611
312.NM.HEART (312.664.3278)

Charles J. Davidson, MD 
Interventional Cardiology
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve Clinical Trials – Aortic Valve: EARLY TAVR, ExCEED, PARTNER 3 CAP, PARTNER 3 Aortic Valve in Valve, TAVR UNLOAD 

James D. Flaherty, MD 
Interventional Cardiology
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve 

Clinical Trials – Aortic Valve: EARLY TAVR, ExCEED, PARTNER 3 CAP, PARTNER 3 Aortic Valve in Valve, TAVR UNLOAD 

Transcatheter Aortic Valve Replacement (TAVR): A minimally invasive treatment option for patients with aortic valve stenosis. A stenotic aortic valve is narrowed, restricting blood flow from the heart. During TAVR, an interventional cardiologist and/or a cardiac surgeon inserts a catheter (tube) in the body through an artery. The TAVR valve is compressed and advanced by a catheter through an artery until it reaches the diseased aortic valve. A balloon on the catheter expands to secure the TAVR valve within the diseased aortic valve and then the catheter is removed. The secured TAVR valve remains in place pushing the diseased valve out of the way, allowing the TAVR valve to take over the job of regulating blood flow from the heart. 

TAVR valve shown in aortic valve position

Mark J. Ricciardi, MD 
Interventional Cardiology
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve 

Clinical Trials – Aortic Valve: EARLY TAVR, ExCEED, PARTNER 3 CAP, PARTNER 3 Aortic Valve in Valve, TAVR UNLOAD 

Ranya N. Sweis, MD 
Interventional Cardiology
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve 

Clinical Trials – Aortic Valve: EARLY TAVR, ExCEED, PARTNER 3 CAP, PARTNER 3 Aortic Valve in Valve 

S. Chris Malaisrie, MD 
Cardiac Surgery
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve 

Clinical Trials – Aortic Valve: EARLY TAVR, ExCEED, PARTNER 3 CAP, PARTNER 3 Aortic Valve in Valve, TAVR UNLOAD 

Andrei Churyla, MD 
Cardiac Surgery
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve 

Clinical Trials – Aortic Valve: ExCEED 

Duc Thinh Pham, MD 
Cardiac Surgery
Commercially Available – Aortic Valve: TAVR, Aortic Valve in Valve 

Clinical Trials – Aortic Valve: EARLY TAVR, ExCEED, PARTNER 3 CAP, PARTNER 3 Aortic Valve in Valve, TAVR UNLOAD 

Imran N. Ahmad, MD 
Interventional Cardiology
Commercially Available –Aortic Valve: TAVR
 

Gyu I. Gang, MD 
Cardiac Surgery
Commercially Available –Aortic Valve: TAVR 

Aortic valve in valve replacement

Northwestern Memorial Hospital 312.NM.HEART (312.664.3278)Central DuPage Hospital 630.232.0280

Jonathan Tomasko, MD 
Cardiac Surgery
Commercially Available –Aortic Valve: TAVR 

Transcatheter Aortic Heart Valve Therapies: Now Available for Low-Risk Surgical Patients 

The Transcatheter Heart Valve Program at Northwestern Medicine began offering transcatheter aortic valve replacement (TAVR) in 2008. For some patients with aortic stenosis, TAVR is an alternative treatment to open heart valve surgery. Since the early days of TAVR, Northwestern Medicine has been a leader in spearheading numerous TAVR clinical trials, helping to expand this therapy in a safe and effective way.  

In 2019, the results of two transcatheter aortic valve clinical trials1 –PARTNER 3 and EVOLUT– suggest that low-risk patients do as well or better with TAVR than with open heart valve surgery to replace a diseased aortic valve. TAVR is not only an option for patients considered medium- or high-risk for open heart valve surgery, but is also an option for younger, healthier, low-risk patients. As one of the top enrolling sites in the United States for the PARTNER 3 clinical trial, we are proud to be leaders in innovating treatment options with easier recoveries and superior results for our patients.

Today, Northwestern Medicine offers a variety of commercially available (FDA approved) TAVR procedures and clinical trial options for the aortic valve, allowing us to tailor treatment precisely to the individual patient’s needs. TAVR therapies are offered at both Northwestern Memorial Hospital and Central DuPage Hospital.  

1. Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients. N Engl J Med, 2019.

Transcatheter Aortic Valve Commercially Available (FDA Approved) Treatment Options

Transcatheter procedures allow the procedure to be performed while the patient’s heart is still beating, eliminating the need for a “heart bypass” machine and its associated risks. Due to the minimally invasive nature of transcatheter procedures, patients tend to recover faster and experience an improvement in symptoms soon after the procedure is completed. The Transcatheter Heart Valve Program at Northwestern Medicine offers two aortic valve transcatheter treatment options: TAVR and transcatheter aortic valve in valve replacement.

Transcatheter Aortic Valve Clinical Trial Options 

Researchers at Northwestern Medicine conduct clinical trials that provide access to innovative therapies for the treatment of heart and vascular disease. Participating in a clinical trial is an opportunity to evaluate the effectiveness and safety of medications or study devices. The study devices and delivery systems used in the following clinical trials are investigational (experimental), which means they are not approved for commercial use by the U.S. FDA.

Bluhm Cardiovascular Institute at Central DuPage Hospital
25 N. Winfield Road
Winfield, IL 60190
630.232.0280

Northwestern Medicine is also among the most experienced programs in the country for transcatheter treatment options for the mitral valve and tricuspid valve.

Video used by permission of Edwards Lifesciences.  

PARTNER 3 CAP: enrolling patients to evaluate the Edwards SAPIEN 3 transcatheter heart valve replacement system in patients who have severe aortic stenosis and are at low operative risk for traditional open heart surgery for aortic valve replacement. The SAPIEN 3 transcatheter aortic heart valve (study device) will be implanted transfemorally (minimally invasive procedure through a puncture in the femoral vein in the leg). Patients with a bicuspid aortic valve (BAV) are eligible to participate. 

EARLY TAVR: enrolling patients with severe aortic stenosis who do not have any symptoms. Eligible participants will be randomized to receive TAVR (transcatheter aortic valve replacement) with the SAPIEN 3 transcatheter aortic heart valve (study device) and the other group will receive medical therapy. 

ExCEED: enrolling patients with symptomatic, severe aortic stenosis who have some (intermediate) risk for undergoing open heart surgery. Eligible patients will have a transcatheter heart valve replacement using the self-expanding Edwards CENTERA device (study device).  

TAVR UNLOAD: enrolling patients with heart failure who have moderate aortic stenosis. Eligible participants will be randomized to receive TAVR (transcatheter aortic valve replacement) with the SAPIEN 3 transcatheter aortic heart valve (study device) OR to receive optimal heart failure therapy. 


PARTNER 3 Aortic Valve in Valve: enrolling patients who have an existing bioprosthetic aortic valve that is failing and needs to be replaced. Eligible participants will receive the SAPIEN 3 transcatheter aortic heart valve (study device) to replace the failing bioprosthetic aortic valve. 

Transcatheter Aortic Valve in Valve Replacement: A minimally invasive TAVR procedure for patients who have had previous open heart valve surgery to replace the aortic valve with a bioprosthetic/tissue valve that is now failing. Instead of replacing the failing aortic valve with another open heart valve surgery, the failing aortic valve is replaced by placing and securing a TAVR valve inside the failing aortic valve. 

During aortic valve in valve replacement, an interventional cardiologist and/or a cardiac surgeon inserts a catheter (tube) through an artery in the body. The TAVR valve is compressed and advanced by a catheter through an artery until it reaches the failing aortic valve. A balloon on the catheter expands and secures the TAVR valve within the failing aortic valve.  The catheter is then removed and the TAVR valve remains in place pushing the failing aortic valve out of the way, allowing the TAVR valve to take over the job of regulating blood flow from the heart. 

We are proud of our U.S. News & World Report cardiology and heart surgery program ranking – a reflection of the leading-edge services we offer and the results we achieve for our patients, their families and the region we serve. 

  • Among the top 10 cardiology and heart surgery programs in the nation (#7) of 590 programs
  • Highest ranked cardiology and heart surgery program in Illinois, and the highest ranked program in the region including Indiana, Michigan, Wisconsin, Missouri and Iowa
  • Achieved the highest available cardiology and heart surgery patient survival score (10 out of 10)